Field Camp Study

High Throughput Vascular Screening with ARTSENS® Pen

“High-throughput vascular screening with ARTSENS Pen during a medical camp for early stage detection of chronic kidney disease”, in 2020 42nd Annual International Conference of IEEE Engineering in Medicine and Biology Society, Montreal, Canada, 2020, pp. 2752-2755.

P. M. Nabeel, R. Manoj, V. V.  Abhidev, J. Joseph, V. Raj Kiran & M. Sivaprakasam.

The high-throughput screening of carotid artery stiffness was performed using ARTSENS Pen during a medical camp conducted for awareness and early-stage detection of kidney diseases.

Using Artsens Pen to detect chronic kidney disease at early stage

Camp duration

5 hours

4 hours for screening tests and a one-hour for awareness session to emphasize the importance of vital organ care and routine health check-up.

Screening procedures

1. Biosample tests (urine and blood analysis) for identifying biomarkers for early-stage kidney disease

2. Measurement of vascular stiffness indices from the carotid artery

Participants

age: 51 ± 12.5 years; 56 males

In which, 48% of the subjects were normal weight, 5% were under-weight, 38% were overweight, and 9% obese subjects.

27% of the subjects had increased blood pres-sure, and 59% were diagnosed with elevated fasting blood sugar.

Nearly 50% of them were masked or untreated hypertensive and/or diabetes patients.

Results and Observations

1. Two units of ARTSENS Pen performed 85 individual measurements and three repeat attempts within 4 hours.

2. The average time taken per subject to complete the entire protocol, including anthropometric measurements, BP monitoring, data entry, and stiffness evaluation, was less than five minutes (range: 2.5 – 5 minutes).

3. The device provided a reliable measure of β (8.93 ± 3.73), EP (125.09 ± 60.32 kPa), diastolic PWV (6.60 ± 1.58 m/s), and systolic PWV (8.13 ± 2.11 m/s).

4. Among these, β and EP exhibited a more evident age-associated increase (R2 ≈ 0.97).

5. All the measured stiffness indices were significantly higher in female subjects, depicting gender differences in the time course of aging-related vascular stiffness.

6. Both PWVs strongly associated with the clustering of multiple biochemical risk factors (R2 > 0.99), followed by EP and β (R2 > 0.97).

Age-related trends in carotid stiffness

Graph to show Age-related trends in carotid stiffness

Gender-specific difference in younger and older population in carotid stiffness

Graph to show Gender-specific difference in younger and older population in carotid stiffness

Variation in carotid stiffness among 0 to 2 risk categories

Graph to show Variation in carotid stiffness among 0 to 2 risk categories.

These results and observations confirm

Artsens Pen Device

ARTSENS Pen as a useful tool for high-throughput vascular screening and analysis of metabolic factors affecting arterial stiffness.